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Powder for solution for injection 1 FL.
zovirax 250 mg
excipients: sodium hydroxide
in the bottle; in a box 5 vials.
Ophthalmic ointment 3% 100 g
zovirax (micronized) 3 g
excipients: Vaseline white to 100 g
in the gathering of 4.5 g; in a cardboard unit 1 tube.
Inhibits the in vitro and in vivo replication of the herpes viruses, including herpes simplex virus (HSV) 1 and 2 types, varicella zoster and postherpetic neuralgia (VOG), Epstein-Barr virus (EBV) and Cytomegalovirus (CMV). In cell culture model has the most pronounced antiviral activity against HSV 1, then in order of decreasing activity follow: HSV 2 VOGT, a WEB and CMV.
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Has low toxicity towards mammalian cells.
After intake of zovirax only partially absorbed from the bowel.
Seniors clearance of zovirax decreases with age in parallel with a decrease in creatinine clearance, however, the T1/2 of zovirax is changed slightly.
In patients with chronic renal insufficiency T1/2 aziklovira averaged 19.5 h, while the average dialysis T1/2 of zovirax was 5.7 h and the concentration of zovirax in plasma decreased by approximately 60%.
zovirax concentration in cerebrospinal fluid is approximately 50% of its plasma concentration. zovirax marginally associated with blood plasma proteins (9-33%), so the drug interactions due to the crowding out of bonding with the squirrels are unlikely.
With the introduction of zovirax and zidovudine to HIV-infected patients pharmacokinetic characteristics of both drugs practically did not change.
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After applying eye ointment zovirax is rapidly absorbed the epithelium of the cornea and okologlaznymi fabrics, resulting in vnutriglazna liquid creates a concentration of the drug required to suppress the virus. After applying eye ointment Zovirax zovirax is defined only in the urine, and in small quantities.
Use during pregnancy
Hypersensitivity to azikloviru or valatzikloviru.
With caution in the on/in the introduction: dehydration, kidney failure, neurological damage, development of reactions to cytotoxic drugs (when they are on/in the introduction) and if any in history, pregnancy.
Inside: dehydration, kidney failure.
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Gastrointestinal: nausea, vomiting; If ingestion is diarrhoea, pain in the abdomen.
Blood system: anemia, lakopenia and thrombocytopenia.
Hypersensitivity reactions and skin: rash, photosensitivity, urticaria, itching, fever; rarely, dizziness, swelling angioneuroticeski, anaphylaxis; the on/in the conduct severe local inflammatory reactions leading to necrosis of the skin, by ingestion solution Zoviraksa under the skin. Liver: reversible raising cium and liver enzymes; the on/in the conduct hepatitis and jaundice (very rare).
CENTRAL NERVOUS SYSTEM: with the/run by such reversible neurological disorders like sputannosti consciousness, hallucinations, agitation, tremor, drowsiness, psychosis, convulsions and coma is usually observed in patients with predraspolagatmi States; If ingestion is a headache; rarely is a reversible neurological disorders.
Other: fatigue; rarely quick diffuse hair loss (relationship with taking zovirax is not installed).
In patients receiving antiretroviral drugs (mainly Retrovir inside), additional admission Zoviraksa that did not produce a meaningful strengthening of toxic effects.
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Immune system: very rare (1/10000 is a hypersensitivity reaction immediate type, including angioneuroticeski syndrome.
On the part of the organ of vision: very frequently (1/10 is a dotted surface keratopathy (does not require stopping treatment and disappears without consequences); often (from 1/100 to 1/10)-slight burning, with time passing, conjunctivitis; rarely (from 1/10000 to 1/1000 is blepharitis.
Dosage and administration
Inside, at the time of delivery, squeezed a full glass of water.
Treatment of infections caused by the herpes simplex virus: the recommended dose is 200 mg Zoviraksa 5 times a day every 4 h, with the exception of the period of night sleep. Usually the course of treatment is 5 days but can be extended with the heavy primary infections.